<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2021 Workiva-->
<!--r:980cce77-15de-4ccd-aec7-04e0a792b3b9,g:0e7bfea3-2e6c-40db-a392-85cac148a805-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://soterahealth.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="shc-20210630.xsd#ConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_17140098-41d2-450e-8fdf-8a4905308629" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetRetirementObligationCurrent_6345ca91-9af3-4cd4-9198-55cb4251c376" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetRetirementObligationCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_17140098-41d2-450e-8fdf-8a4905308629" xlink:to="loc_us-gaap_AssetRetirementObligationCurrent_6345ca91-9af3-4cd4-9198-55cb4251c376" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_ecbc2b43-17d5-43e9-aef7-4b60c9266186" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_17140098-41d2-450e-8fdf-8a4905308629" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_ecbc2b43-17d5-43e9-aef7-4b60c9266186" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_6109d98b-e311-4e39-a5b0-089a48ea30b0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_17140098-41d2-450e-8fdf-8a4905308629" xlink:to="loc_us-gaap_AccountsPayableCurrent_6109d98b-e311-4e39-a5b0-089a48ea30b0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityCurrent_a9d05fc4-d351-419d-a7a3-84ecd50914ad" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinanceLeaseLiabilityCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_17140098-41d2-450e-8fdf-8a4905308629" xlink:to="loc_us-gaap_FinanceLeaseLiabilityCurrent_a9d05fc4-d351-419d-a7a3-84ecd50914ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_a0779dfd-5640-4189-85f3-ef554d2cdcf5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_17140098-41d2-450e-8fdf-8a4905308629" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_a0779dfd-5640-4189-85f3-ef554d2cdcf5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_c4ea5391-ae25-44ff-ab6f-55fb20590d2d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_17140098-41d2-450e-8fdf-8a4905308629" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_c4ea5391-ae25-44ff-ab6f-55fb20590d2d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_9932fce9-a9a2-4b2b-8f62-1356b5b52ae7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedIncomeTaxesCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_17140098-41d2-450e-8fdf-8a4905308629" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_9932fce9-a9a2-4b2b-8f62-1356b5b52ae7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_2a3357a0-8d53-4237-9998-fb495658ab9b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_0fed95a0-1010-4a5c-84b8-013e546566e7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_2a3357a0-8d53-4237-9998-fb495658ab9b" xlink:to="loc_us-gaap_PreferredStockValue_0fed95a0-1010-4a5c-84b8-013e546566e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_8b751c0e-6a45-4ac9-bc8b-b306287e4dd3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_2a3357a0-8d53-4237-9998-fb495658ab9b" xlink:to="loc_us-gaap_AdditionalPaidInCapital_8b751c0e-6a45-4ac9-bc8b-b306287e4dd3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_97158be9-5dcb-4829-9a64-4434d9a6c31d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_2a3357a0-8d53-4237-9998-fb495658ab9b" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_97158be9-5dcb-4829-9a64-4434d9a6c31d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_10a5c3cc-20ba-455a-a541-9dd946ef4252" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_2a3357a0-8d53-4237-9998-fb495658ab9b" xlink:to="loc_us-gaap_CommonStockValue_10a5c3cc-20ba-455a-a541-9dd946ef4252" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_259fb1bf-e39e-4afc-8ee3-769dd93ca456" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockValue"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_2a3357a0-8d53-4237-9998-fb495658ab9b" xlink:to="loc_us-gaap_TreasuryStockValue_259fb1bf-e39e-4afc-8ee3-769dd93ca456" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_3d223dcf-279b-48cc-a2ba-50d65e2ab96a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_2a3357a0-8d53-4237-9998-fb495658ab9b" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_3d223dcf-279b-48cc-a2ba-50d65e2ab96a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_b532b9a2-e35c-48b8-8176-f764a6af1c32" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashCurrent_bfb51193-3154-455d-a48b-b2e19bd7dffb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedCashCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_b532b9a2-e35c-48b8-8176-f764a6af1c32" xlink:to="loc_us-gaap_RestrictedCashCurrent_bfb51193-3154-455d-a48b-b2e19bd7dffb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_c4392357-95d0-449d-a852-0d96b5926f32" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_b532b9a2-e35c-48b8-8176-f764a6af1c32" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_c4392357-95d0-449d-a852-0d96b5926f32" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_a098db68-1176-44cc-9b07-e3d07474821b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_b532b9a2-e35c-48b8-8176-f764a6af1c32" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_a098db68-1176-44cc-9b07-e3d07474821b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_d38af649-dee8-470e-9e9d-b7df7aaae026" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_b532b9a2-e35c-48b8-8176-f764a6af1c32" xlink:to="loc_us-gaap_InventoryNet_d38af649-dee8-470e-9e9d-b7df7aaae026" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_c865e864-8379-4cd1-b6d1-ae7f00359f97" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_b532b9a2-e35c-48b8-8176-f764a6af1c32" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_c865e864-8379-4cd1-b6d1-ae7f00359f97" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxesReceivable_306fd569-1ab3-4cb2-94e8-d3e9918a5a3b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxesReceivable"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_b532b9a2-e35c-48b8-8176-f764a6af1c32" xlink:to="loc_us-gaap_IncomeTaxesReceivable_306fd569-1ab3-4cb2-94e8-d3e9918a5a3b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_f12217b4-83d6-4de6-9789-b54ba525bed9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_f3adedb7-63f9-493b-b406-4be7722daf82" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_f12217b4-83d6-4de6-9789-b54ba525bed9" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_f3adedb7-63f9-493b-b406-4be7722daf82" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_f6fe3b32-6f84-4027-8bd5-ae0938abea0c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_f12217b4-83d6-4de6-9789-b54ba525bed9" xlink:to="loc_us-gaap_Liabilities_f6fe3b32-6f84-4027-8bd5-ae0938abea0c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_932f7aed-117d-45c0-9e0b-d8078db55d3d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_f12217b4-83d6-4de6-9789-b54ba525bed9" xlink:to="loc_us-gaap_CommitmentsAndContingencies_932f7aed-117d-45c0-9e0b-d8078db55d3d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_a805ddd6-f3eb-49c5-9a72-01130ac0d01b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetRetirementObligationsNoncurrent_371b827d-8c4d-4997-a859-8673db6283a6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetRetirementObligationsNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_a805ddd6-f3eb-49c5-9a72-01130ac0d01b" xlink:to="loc_us-gaap_AssetRetirementObligationsNoncurrent_371b827d-8c4d-4997-a859-8673db6283a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_ed0aeb98-2ed2-4323-a717-d1f19a4de2bc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_a805ddd6-f3eb-49c5-9a72-01130ac0d01b" xlink:to="loc_us-gaap_LongTermDebt_ed0aeb98-2ed2-4323-a717-d1f19a4de2bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesSubjectToMandatoryRedemptionSettlementTermsAmountNoncurrent_910492b6-843e-4d9d-b52c-f1c427cd7c1f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharesSubjectToMandatoryRedemptionSettlementTermsAmountNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_a805ddd6-f3eb-49c5-9a72-01130ac0d01b" xlink:to="loc_us-gaap_SharesSubjectToMandatoryRedemptionSettlementTermsAmountNoncurrent_910492b6-843e-4d9d-b52c-f1c427cd7c1f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRentCreditNoncurrent_5792a014-e072-43d7-8e3e-0c32a03b9d41" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredRentCreditNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_a805ddd6-f3eb-49c5-9a72-01130ac0d01b" xlink:to="loc_us-gaap_DeferredRentCreditNoncurrent_5792a014-e072-43d7-8e3e-0c32a03b9d41" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_159e7b82-2f5a-47ea-aa97-04f3e3efb3e9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_a805ddd6-f3eb-49c5-9a72-01130ac0d01b" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_159e7b82-2f5a-47ea-aa97-04f3e3efb3e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_68d73cb6-e828-42d5-881b-bbbb1f8479a1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_a805ddd6-f3eb-49c5-9a72-01130ac0d01b" xlink:to="loc_us-gaap_LiabilitiesCurrent_68d73cb6-e828-42d5-881b-bbbb1f8479a1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_a997302f-33b6-4172-9658-cfad5a1abb79" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_a805ddd6-f3eb-49c5-9a72-01130ac0d01b" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_a997302f-33b6-4172-9658-cfad5a1abb79" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionAndOtherPostretirementAndPostemploymentBenefitPlansLiabilitiesNoncurrent_fc03ac95-1b74-4b40-977a-203387d8b87b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PensionAndOtherPostretirementAndPostemploymentBenefitPlansLiabilitiesNoncurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_a805ddd6-f3eb-49c5-9a72-01130ac0d01b" xlink:to="loc_us-gaap_PensionAndOtherPostretirementAndPostemploymentBenefitPlansLiabilitiesNoncurrent_fc03ac95-1b74-4b40-977a-203387d8b87b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_edff879d-1be0-4e36-aa3c-44a0f2fcc2f4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_a805ddd6-f3eb-49c5-9a72-01130ac0d01b" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_edff879d-1be0-4e36-aa3c-44a0f2fcc2f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_a2f9b2b0-73fc-4cc6-a622-edd18b5eaf52" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_a805ddd6-f3eb-49c5-9a72-01130ac0d01b" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_a2f9b2b0-73fc-4cc6-a622-edd18b5eaf52" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_a6d262c7-3f0a-473e-9206-c97e53c80b16" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterest_4bbf0f00-7eaf-4d32-84ff-1b7a74e6ed64" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MinorityInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_a6d262c7-3f0a-473e-9206-c97e53c80b16" xlink:to="loc_us-gaap_MinorityInterest_4bbf0f00-7eaf-4d32-84ff-1b7a74e6ed64" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_f3be2601-b49c-4222-aebf-1f8cb03cdd7d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_a6d262c7-3f0a-473e-9206-c97e53c80b16" xlink:to="loc_us-gaap_StockholdersEquity_f3be2601-b49c-4222-aebf-1f8cb03cdd7d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_8f89e100-1dba-41c4-b8fe-26b946537075" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_33840bd7-5e1f-42e8-babe-db4f1ef534c9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8f89e100-1dba-41c4-b8fe-26b946537075" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_33840bd7-5e1f-42e8-babe-db4f1ef534c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestments_a320972e-fdb3-4b8b-8790-902fc6b05e4f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityMethodInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8f89e100-1dba-41c4-b8fe-26b946537075" xlink:to="loc_us-gaap_EquityMethodInvestments_a320972e-fdb3-4b8b-8790-902fc6b05e4f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_ad04b07f-8b1b-489f-b230-d5ad5d4665ff" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8f89e100-1dba-41c4-b8fe-26b946537075" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_ad04b07f-8b1b-489f-b230-d5ad5d4665ff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_a4ecb66f-7a8e-4669-867b-c6fbda241476" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8f89e100-1dba-41c4-b8fe-26b946537075" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_a4ecb66f-7a8e-4669-867b-c6fbda241476" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_e2f02791-0e28-4ac8-b4f9-8740979ebf57" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8f89e100-1dba-41c4-b8fe-26b946537075" xlink:to="loc_us-gaap_AssetsCurrent_e2f02791-0e28-4ac8-b4f9-8740979ebf57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_53d60be0-2445-4fb7-ae0d-ec4e9f8e01d8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8f89e100-1dba-41c4-b8fe-26b946537075" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_53d60be0-2445-4fb7-ae0d-ec4e9f8e01d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_abfe1e7e-356d-4b10-b615-adf38ee9a4fd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8f89e100-1dba-41c4-b8fe-26b946537075" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_abfe1e7e-356d-4b10-b615-adf38ee9a4fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_ec5f3b09-741b-472b-96ed-677e6d1c549b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8f89e100-1dba-41c4-b8fe-26b946537075" xlink:to="loc_us-gaap_Goodwill_ec5f3b09-741b-472b-96ed-677e6d1c549b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/ConsolidatedStatementsofOperationsandComprehensiveIncomeLoss" xlink:type="simple" xlink:href="shc-20210630.xsd#ConsolidatedStatementsofOperationsandComprehensiveIncomeLoss"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/ConsolidatedStatementsofOperationsandComprehensiveIncomeLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_418f447e-deab-4e35-9ad6-eeb92f8137d9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_ef21bab1-a8b0-488c-8c0e-69df649aecbd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_418f447e-deab-4e35-9ad6-eeb92f8137d9" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_ef21bab1-a8b0-488c-8c0e-69df649aecbd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_1ce9087e-fd3e-4555-9bbf-e57738b4b970" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_418f447e-deab-4e35-9ad6-eeb92f8137d9" xlink:to="loc_us-gaap_OperatingIncomeLoss_1ce9087e-fd3e-4555-9bbf-e57738b4b970" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_633ffb6c-bc47-4502-8656-74be1267db51" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_418f447e-deab-4e35-9ad6-eeb92f8137d9" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_633ffb6c-bc47-4502-8656-74be1267db51" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_bccf4277-4257-4426-8a5c-99acebcb600a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_418f447e-deab-4e35-9ad6-eeb92f8137d9" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_bccf4277-4257-4426-8a5c-99acebcb600a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_d9db3a80-cda0-463d-9e8b-67c616dff0c5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_418f447e-deab-4e35-9ad6-eeb92f8137d9" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_d9db3a80-cda0-463d-9e8b-67c616dff0c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_4c2bfd4c-ed67-4a41-96ae-2515b2291ba8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_15f1dad8-02a6-4ee2-85f0-8ca6ff9a7091" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_4c2bfd4c-ed67-4a41-96ae-2515b2291ba8" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_15f1dad8-02a6-4ee2-85f0-8ca6ff9a7091" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_AmortizationOfIntangibleAssetsNonproduction_608f0bef-ae28-4433-8a79-02dbc670a479" xlink:href="shc-20210630.xsd#shc_AmortizationOfIntangibleAssetsNonproduction"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_4c2bfd4c-ed67-4a41-96ae-2515b2291ba8" xlink:to="loc_shc_AmortizationOfIntangibleAssetsNonproduction_608f0bef-ae28-4433-8a79-02dbc670a479" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_275e4e94-19f7-4060-b768-ff7ce8fb9aca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_b46fbbcb-d9cd-442e-a81b-83742f78102e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_275e4e94-19f7-4060-b768-ff7ce8fb9aca" xlink:to="loc_us-gaap_OperatingExpenses_b46fbbcb-d9cd-442e-a81b-83742f78102e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_a7961349-eff2-4973-aafe-44837ca97bb4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_275e4e94-19f7-4060-b768-ff7ce8fb9aca" xlink:to="loc_us-gaap_GrossProfit_a7961349-eff2-4973-aafe-44837ca97bb4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_ec82d20e-1591-4519-9658-24b075f697b1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_52c46fbf-7f3a-49c3-8852-22bd27872f66" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_ec82d20e-1591-4519-9658-24b075f697b1" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_52c46fbf-7f3a-49c3-8852-22bd27872f66" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_21c44952-ff4f-4574-be25-5182444f4481" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_ec82d20e-1591-4519-9658-24b075f697b1" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_21c44952-ff4f-4574-be25-5182444f4481" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_79b50a89-a762-4fc6-b2b2-fe97024e1a11" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_c9b436c0-ea83-45d6-87fc-1767820eee48" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_79b50a89-a762-4fc6-b2b2-fe97024e1a11" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_c9b436c0-ea83-45d6-87fc-1767820eee48" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_27100f43-933d-4bcc-a673-659eb3ced299" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_79b50a89-a762-4fc6-b2b2-fe97024e1a11" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_27100f43-933d-4bcc-a673-659eb3ced299" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_dd4c1f5c-3889-4dc5-b483-47ca2f273428" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_1278885d-dcd7-47db-9114-f11a578cc837" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostOfRevenue"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_dd4c1f5c-3889-4dc5-b483-47ca2f273428" xlink:to="loc_us-gaap_CostOfRevenue_1278885d-dcd7-47db-9114-f11a578cc837" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_a6aec2e3-097a-4f33-8dda-15f0661b7b9a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_dd4c1f5c-3889-4dc5-b483-47ca2f273428" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_a6aec2e3-097a-4f33-8dda-15f0661b7b9a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_2a77a93f-a505-4cae-92c0-12c8c0182704" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_6028ade5-019e-44e0-b975-32b08ca96471" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_2a77a93f-a505-4cae-92c0-12c8c0182704" xlink:to="loc_us-gaap_ProfitLoss_6028ade5-019e-44e0-b975-32b08ca96471" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_e498569b-68e3-4acf-b8ab-2fc0fadf9c29" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_2a77a93f-a505-4cae-92c0-12c8c0182704" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_e498569b-68e3-4acf-b8ab-2fc0fadf9c29" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_5d0f908f-7d1d-473c-853c-cffb80bb880e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_743e2a5b-81fc-47f6-97d8-51164d67c051" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_5d0f908f-7d1d-473c-853c-cffb80bb880e" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_743e2a5b-81fc-47f6-97d8-51164d67c051" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_025ccd35-0817-421a-85d9-f973d0025792" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_5d0f908f-7d1d-473c-853c-cffb80bb880e" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_025ccd35-0817-421a-85d9-f973d0025792" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_158be348-3f99-4176-9c4d-8d50402ada0f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_5d0f908f-7d1d-473c-853c-cffb80bb880e" xlink:to="loc_us-gaap_ProfitLoss_158be348-3f99-4176-9c4d-8d50402ada0f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_4ce00cec-b346-4e90-8c14-622145e89310" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_5d0f908f-7d1d-473c-853c-cffb80bb880e" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_4ce00cec-b346-4e90-8c14-622145e89310" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/ConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="shc-20210630.xsd#ConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/ConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4da7ae42-de51-43d4-a9fa-836cfc5f8073" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_a73b1267-8628-4885-8768-5b4e0181ea0a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4da7ae42-de51-43d4-a9fa-836cfc5f8073" xlink:to="loc_us-gaap_ProfitLoss_a73b1267-8628-4885-8768-5b4e0181ea0a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_d03e2834-ae98-45e4-9836-61f55e0dd18f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4da7ae42-de51-43d4-a9fa-836cfc5f8073" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_d03e2834-ae98-45e4-9836-61f55e0dd18f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherCurrentAssets_63909ab2-29c4-480b-b3d8-74fcd40b1c17" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInOtherCurrentAssets"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4da7ae42-de51-43d4-a9fa-836cfc5f8073" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherCurrentAssets_63909ab2-29c4-480b-b3d8-74fcd40b1c17" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_207a4ec1-1400-4702-87bf-ba6b5e110a8e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4da7ae42-de51-43d4-a9fa-836cfc5f8073" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_207a4ec1-1400-4702-87bf-ba6b5e110a8e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_58e7f063-665e-42cb-b50b-7f073df854ae" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4da7ae42-de51-43d4-a9fa-836cfc5f8073" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_58e7f063-665e-42cb-b50b-7f073df854ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossUnrealized_a25dc74e-e8d1-4b8b-9288-c215e64e638c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ForeignCurrencyTransactionGainLossUnrealized"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4da7ae42-de51-43d4-a9fa-836cfc5f8073" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossUnrealized_a25dc74e-e8d1-4b8b-9288-c215e64e638c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_9c70bdc4-b50c-4bec-a4bf-40953f2c6e19" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4da7ae42-de51-43d4-a9fa-836cfc5f8073" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_9c70bdc4-b50c-4bec-a4bf-40953f2c6e19" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_aad1fd5e-2e6d-48c3-be69-ebfa96135772" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4da7ae42-de51-43d4-a9fa-836cfc5f8073" xlink:to="loc_us-gaap_Depreciation_aad1fd5e-2e6d-48c3-be69-ebfa96135772" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetRetirementObligationAccretionExpense_84ae1104-c8cd-47cf-9785-e6d5af322134" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetRetirementObligationAccretionExpense"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4da7ae42-de51-43d4-a9fa-836cfc5f8073" xlink:to="loc_us-gaap_AssetRetirementObligationAccretionExpense_84ae1104-c8cd-47cf-9785-e6d5af322134" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_4c1b7123-cbf7-4173-a1af-e58e0b2c8354" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4da7ae42-de51-43d4-a9fa-836cfc5f8073" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_4c1b7123-cbf7-4173-a1af-e58e0b2c8354" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_d629388d-0900-44ec-beda-c7870bf49bf5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4da7ae42-de51-43d4-a9fa-836cfc5f8073" xlink:to="loc_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_d629388d-0900-44ec-beda-c7870bf49bf5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_5c330179-7628-4f0b-becb-19c8c70e759c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4da7ae42-de51-43d4-a9fa-836cfc5f8073" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_5c330179-7628-4f0b-becb-19c8c70e759c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_37db441e-842f-4238-abf9-fe8e1082865b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4da7ae42-de51-43d4-a9fa-836cfc5f8073" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_37db441e-842f-4238-abf9-fe8e1082865b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_0dd449c1-8fc3-4027-a359-24e8227b7e1d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4da7ae42-de51-43d4-a9fa-836cfc5f8073" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_0dd449c1-8fc3-4027-a359-24e8227b7e1d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_c6395127-f5ac-4224-bf60-89ec1d80dae5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="15" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4da7ae42-de51-43d4-a9fa-836cfc5f8073" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_c6395127-f5ac-4224-bf60-89ec1d80dae5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_1197a64e-a37a-44db-85c4-eaaeaa535efb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4da7ae42-de51-43d4-a9fa-836cfc5f8073" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_1197a64e-a37a-44db-85c4-eaaeaa535efb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_52aa477c-be83-4f5f-ab22-66c112264501" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="17" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4da7ae42-de51-43d4-a9fa-836cfc5f8073" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_52aa477c-be83-4f5f-ab22-66c112264501" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_8dcd55c9-b8a7-41f6-b375-b9fed2fb9f5d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="18" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4da7ae42-de51-43d4-a9fa-836cfc5f8073" xlink:to="loc_us-gaap_ShareBasedCompensation_8dcd55c9-b8a7-41f6-b375-b9fed2fb9f5d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_cf97a67f-c987-4163-9103-e18105bff521" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="19" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4da7ae42-de51-43d4-a9fa-836cfc5f8073" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_cf97a67f-c987-4163-9103-e18105bff521" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3a11c798-c6ae-4d40-9dd7-fe6bb919ce58" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e9393a88-d884-4711-849b-4c097fbc8688" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3a11c798-c6ae-4d40-9dd7-fe6bb919ce58" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e9393a88-d884-4711-849b-4c097fbc8688" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_e40b983f-d270-458d-bcad-21a22ac0d913" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3a11c798-c6ae-4d40-9dd7-fe6bb919ce58" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_e40b983f-d270-458d-bcad-21a22ac0d913" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_dd339090-2e84-4b67-9b46-ac996c7ed138" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3a11c798-c6ae-4d40-9dd7-fe6bb919ce58" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_dd339090-2e84-4b67-9b46-ac996c7ed138" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_ad4a950d-43c8-4da4-bd32-b84c4cb235a3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3a11c798-c6ae-4d40-9dd7-fe6bb919ce58" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_ad4a950d-43c8-4da4-bd32-b84c4cb235a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_023756df-3a96-4906-a658-0c3a268f991c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_bd97949b-9c8f-4c29-899d-392e87a1cf5d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_023756df-3a96-4906-a658-0c3a268f991c" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_bd97949b-9c8f-4c29-899d-392e87a1cf5d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToMinorityShareholders_ce3d9e71-0543-4655-bba4-a3214cbe5a00" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToMinorityShareholders"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_023756df-3a96-4906-a658-0c3a268f991c" xlink:to="loc_us-gaap_PaymentsToMinorityShareholders_ce3d9e71-0543-4655-bba4-a3214cbe5a00" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_38428bf4-21c0-4d2a-a36a-6abbbb8ef963" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_023756df-3a96-4906-a658-0c3a268f991c" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_38428bf4-21c0-4d2a-a36a-6abbbb8ef963" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromLongTermLinesOfCredit_b2f480ea-a55f-424f-8112-317d89e50caf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromLongTermLinesOfCredit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_023756df-3a96-4906-a658-0c3a268f991c" xlink:to="loc_us-gaap_ProceedsFromLongTermLinesOfCredit_b2f480ea-a55f-424f-8112-317d89e50caf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_9128f471-b063-456c-87e1-d615d3382a67" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_023756df-3a96-4906-a658-0c3a268f991c" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_9128f471-b063-456c-87e1-d615d3382a67" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_1fef9163-705f-452a-a6fa-d87dbd415f5c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_089f656b-34ce-4136-b8b5-88e154d135e0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_1fef9163-705f-452a-a6fa-d87dbd415f5c" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_089f656b-34ce-4136-b8b5-88e154d135e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAdditionalInterestInSubsidiaries_ae2b0da1-0a53-494a-b695-1ba69eab5b52" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireAdditionalInterestInSubsidiaries"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_1fef9163-705f-452a-a6fa-d87dbd415f5c" xlink:to="loc_us-gaap_PaymentsToAcquireAdditionalInterestInSubsidiaries_ae2b0da1-0a53-494a-b695-1ba69eab5b52" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_3cb831f8-e3f4-4354-966b-5c821bb16f4f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_1fef9163-705f-452a-a6fa-d87dbd415f5c" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_3cb831f8-e3f4-4354-966b-5c821bb16f4f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/AcquisitionsPurchasePriceAllocationDetails" xlink:type="simple" xlink:href="shc-20210630.xsd#AcquisitionsPurchasePriceAllocationDetails"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/AcquisitionsPurchasePriceAllocationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentConsiderationTransferred_e0b10eeb-fdbb-4b25-a881-74157f2212b3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentConsiderationTransferred"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentOtherAssetsLiabilitiesNet_a208566b-55a6-42d8-81de-89162f065f15" xlink:href="shc-20210630.xsd#shc_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentOtherAssetsLiabilitiesNet"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentConsiderationTransferred_e0b10eeb-fdbb-4b25-a881-74157f2212b3" xlink:to="loc_shc_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentOtherAssetsLiabilitiesNet_a208566b-55a6-42d8-81de-89162f065f15" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentPropertyPlantAndEquipment_29fe7800-c32e-48a0-b039-2e868b3981a3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentConsiderationTransferred_e0b10eeb-fdbb-4b25-a881-74157f2212b3" xlink:to="loc_us-gaap_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentPropertyPlantAndEquipment_29fe7800-c32e-48a0-b039-2e868b3981a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentNoncurrentLiabilitiesOther_901d50ea-8440-4ef2-a98f-d779a0e5dc43" xlink:href="shc-20210630.xsd#shc_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentNoncurrentLiabilitiesOther"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentConsiderationTransferred_e0b10eeb-fdbb-4b25-a881-74157f2212b3" xlink:to="loc_shc_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentNoncurrentLiabilitiesOther_901d50ea-8440-4ef2-a98f-d779a0e5dc43" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentWorkingCapitalNet_12bed775-274b-42ce-a2c8-9e1c586b6dc6" xlink:href="shc-20210630.xsd#shc_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentWorkingCapitalNet"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentConsiderationTransferred_e0b10eeb-fdbb-4b25-a881-74157f2212b3" xlink:to="loc_shc_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentWorkingCapitalNet_12bed775-274b-42ce-a2c8-9e1c586b6dc6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentInvestmentInUnconsolidatedAffiliate_d85ec9cf-d401-4b97-b609-06435d6de6a6" xlink:href="shc-20210630.xsd#shc_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentInvestmentInUnconsolidatedAffiliate"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentConsiderationTransferred_e0b10eeb-fdbb-4b25-a881-74157f2212b3" xlink:to="loc_shc_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentInvestmentInUnconsolidatedAffiliate_d85ec9cf-d401-4b97-b609-06435d6de6a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentIntangibles_a4ef39be-fe8b-4643-8cf8-e0d943e91420" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentIntangibles"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentConsiderationTransferred_e0b10eeb-fdbb-4b25-a881-74157f2212b3" xlink:to="loc_us-gaap_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentIntangibles_a4ef39be-fe8b-4643-8cf8-e0d943e91420" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillPurchaseAccountingAdjustments_db6362ec-eb7c-45ce-91f1-e3577df040c1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillPurchaseAccountingAdjustments"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentConsiderationTransferred_e0b10eeb-fdbb-4b25-a881-74157f2212b3" xlink:to="loc_us-gaap_GoodwillPurchaseAccountingAdjustments_db6362ec-eb7c-45ce-91f1-e3577df040c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_2feae5a4-ae35-44c9-acda-9ce9bf3e4fb6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssetsLiabilitiesNet_b87aac3a-58f9-4c62-8d75-18883372e168" xlink:href="shc-20210630.xsd#shc_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssetsLiabilitiesNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_2feae5a4-ae35-44c9-acda-9ce9bf3e4fb6" xlink:to="loc_shc_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssetsLiabilitiesNet_b87aac3a-58f9-4c62-8d75-18883372e168" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_cc793fa0-578b-4229-b63b-52144e4e1aa5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_2feae5a4-ae35-44c9-acda-9ce9bf3e4fb6" xlink:to="loc_us-gaap_Goodwill_cc793fa0-578b-4229-b63b-52144e4e1aa5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_9e5e5dc6-3df2-4422-86e3-16f9a4166101" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_2feae5a4-ae35-44c9-acda-9ce9bf3e4fb6" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_9e5e5dc6-3df2-4422-86e3-16f9a4166101" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_974e4820-5602-4441-9e5e-7816859d6dee" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_2feae5a4-ae35-44c9-acda-9ce9bf3e4fb6" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_974e4820-5602-4441-9e5e-7816859d6dee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedWorkingCapitalNet_a67c3d56-8e5f-4554-bc70-d2db894438ac" xlink:href="shc-20210630.xsd#shc_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedWorkingCapitalNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_2feae5a4-ae35-44c9-acda-9ce9bf3e4fb6" xlink:to="loc_shc_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedWorkingCapitalNet_a67c3d56-8e5f-4554-bc70-d2db894438ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInvestmentInUnconsolidatedAffiliate_ff4aface-1651-493a-b800-c134901f45e7" xlink:href="shc-20210630.xsd#shc_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInvestmentInUnconsolidatedAffiliate"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_2feae5a4-ae35-44c9-acda-9ce9bf3e4fb6" xlink:to="loc_shc_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInvestmentInUnconsolidatedAffiliate_ff4aface-1651-493a-b800-c134901f45e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_0c9ba056-2903-4a25-878c-0d18ad6c79ae" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_2feae5a4-ae35-44c9-acda-9ce9bf3e4fb6" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_0c9ba056-2903-4a25-878c-0d18ad6c79ae" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/InventoriesDetails" xlink:type="simple" xlink:href="shc-20210630.xsd#InventoriesDetails"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/InventoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_31791d7d-c787-4fed-bab2-e8dfc535d4f2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryGross_3109ad24-1bad-41b8-80b3-2bf40935a20e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_31791d7d-c787-4fed-bab2-e8dfc535d4f2" xlink:to="loc_us-gaap_InventoryGross_3109ad24-1bad-41b8-80b3-2bf40935a20e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryAdjustments_f86b679e-ca5a-4280-aaf3-5cd54e5f33cd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryAdjustments"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_31791d7d-c787-4fed-bab2-e8dfc535d4f2" xlink:to="loc_us-gaap_InventoryAdjustments_f86b679e-ca5a-4280-aaf3-5cd54e5f33cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryGross_046193d1-8aea-4376-80a6-c0ed5ee521f5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoods_25717622-d7de-4a84-82b6-c5de0f9d39fc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryFinishedGoods"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryGross_046193d1-8aea-4376-80a6-c0ed5ee521f5" xlink:to="loc_us-gaap_InventoryFinishedGoods_25717622-d7de-4a84-82b6-c5de0f9d39fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcess_e29d5491-ab5f-4e1e-87fd-ebf3e19193f7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryWorkInProcess"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryGross_046193d1-8aea-4376-80a6-c0ed5ee521f5" xlink:to="loc_us-gaap_InventoryWorkInProcess_e29d5491-ab5f-4e1e-87fd-ebf3e19193f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsAndSupplies_fde83a91-f58d-42af-a8b0-0a9878795108" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryRawMaterialsAndSupplies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryGross_046193d1-8aea-4376-80a6-c0ed5ee521f5" xlink:to="loc_us-gaap_InventoryRawMaterialsAndSupplies_fde83a91-f58d-42af-a8b0-0a9878795108" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/PrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="simple" xlink:href="shc-20210630.xsd#PrepaidExpensesandOtherCurrentAssetsDetails"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/PrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_32952fe6-f28e-4015-ac5d-2f67692fee4f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValueAddedTaxReceivableCurrent_713a9b94-1d01-4305-94ac-be68b511ae0f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ValueAddedTaxReceivableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_32952fe6-f28e-4015-ac5d-2f67692fee4f" xlink:to="loc_us-gaap_ValueAddedTaxReceivableCurrent_713a9b94-1d01-4305-94ac-be68b511ae0f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_PrepaidSoftwareLicensingCurrent_21bbd71e-2cf3-4f32-875b-71aeb91dd06c" xlink:href="shc-20210630.xsd#shc_PrepaidSoftwareLicensingCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_32952fe6-f28e-4015-ac5d-2f67692fee4f" xlink:to="loc_shc_PrepaidSoftwareLicensingCurrent_21bbd71e-2cf3-4f32-875b-71aeb91dd06c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidInsurance_ade54284-1890-48ec-a47a-93583c68619a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidInsurance"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_32952fe6-f28e-4015-ac5d-2f67692fee4f" xlink:to="loc_us-gaap_PrepaidInsurance_ade54284-1890-48ec-a47a-93583c68619a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidRent_4d7f6d1d-dc8c-422c-99b7-b549782c8eef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidRent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_32952fe6-f28e-4015-ac5d-2f67692fee4f" xlink:to="loc_us-gaap_PrepaidRent_4d7f6d1d-dc8c-422c-99b7-b549782c8eef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetNetCurrent_3a2fc712-4c0c-4e84-9d9e-b1bd944a9cef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractWithCustomerAssetNetCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_32952fe6-f28e-4015-ac5d-2f67692fee4f" xlink:to="loc_us-gaap_ContractWithCustomerAssetNetCurrent_3a2fc712-4c0c-4e84-9d9e-b1bd944a9cef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidTaxes_2a3e80a6-af55-48b4-af32-3890901e2fe5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidTaxes"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_32952fe6-f28e-4015-ac5d-2f67692fee4f" xlink:to="loc_us-gaap_PrepaidTaxes_2a3e80a6-af55-48b4-af32-3890901e2fe5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_PrepaidMaintenanceContractsCurrent_53f98b31-e67b-4450-ae67-f95d1d78ae67" xlink:href="shc-20210630.xsd#shc_PrepaidMaintenanceContractsCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_32952fe6-f28e-4015-ac5d-2f67692fee4f" xlink:to="loc_shc_PrepaidMaintenanceContractsCurrent_53f98b31-e67b-4450-ae67-f95d1d78ae67" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InsuranceSettlementsReceivableCurrent_f9d0edbf-6549-40c1-9550-b36184b64593" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InsuranceSettlementsReceivableCurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_32952fe6-f28e-4015-ac5d-2f67692fee4f" xlink:to="loc_us-gaap_InsuranceSettlementsReceivableCurrent_f9d0edbf-6549-40c1-9550-b36184b64593" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Supplies_7d51d9d0-5f81-42df-96c6-684880f41e76" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Supplies"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_32952fe6-f28e-4015-ac5d-2f67692fee4f" xlink:to="loc_us-gaap_Supplies_7d51d9d0-5f81-42df-96c6-684880f41e76" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_9ff2421e-5bd6-4917-b539-3186adf76419" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_32952fe6-f28e-4015-ac5d-2f67692fee4f" xlink:to="loc_us-gaap_OtherAssetsCurrent_9ff2421e-5bd6-4917-b539-3186adf76419" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeAsset_e2e2570c-b514-4301-9e69-7e86f9b6a9ab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeAsset"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_32952fe6-f28e-4015-ac5d-2f67692fee4f" xlink:to="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeAsset_e2e2570c-b514-4301-9e69-7e86f9b6a9ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositsAssetsCurrent_52f628e0-5c51-41f8-b830-a6e63b28ef79" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepositsAssetsCurrent"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_32952fe6-f28e-4015-ac5d-2f67692fee4f" xlink:to="loc_us-gaap_DepositsAssetsCurrent_52f628e0-5c51-41f8-b830-a6e63b28ef79" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/GoodwillandOtherIntangibleAssetsIntangiblesDetails" xlink:type="simple" xlink:href="shc-20210630.xsd#GoodwillandOtherIntangibleAssetsIntangiblesDetails"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/GoodwillandOtherIntangibleAssetsIntangiblesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_3ee33943-08a3-48f8-895b-ac76981461f6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_c878b9fe-df28-47f5-8ed3-6ce2280f8132" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_3ee33943-08a3-48f8-895b-ac76981461f6" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_c878b9fe-df28-47f5-8ed3-6ce2280f8132" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_4f39b720-444f-4464-ad28-18975fa46cd4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_3ee33943-08a3-48f8-895b-ac76981461f6" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_4f39b720-444f-4464-ad28-18975fa46cd4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/GoodwillandOtherIntangibleAssetsFutureAmortizationExpenseDetails" xlink:type="simple" xlink:href="shc-20210630.xsd#GoodwillandOtherIntangibleAssetsFutureAmortizationExpenseDetails"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/GoodwillandOtherIntangibleAssetsFutureAmortizationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_3064cbaf-0754-4a22-8405-93d585a5b46b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour_b2ae4252-6c75-473c-923f-209ae2236b08" xlink:href="shc-20210630.xsd#shc_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_3064cbaf-0754-4a22-8405-93d585a5b46b" xlink:to="loc_shc_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour_b2ae4252-6c75-473c-923f-209ae2236b08" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_b29c36f2-053d-4323-b87d-09fcf731df78" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_3064cbaf-0754-4a22-8405-93d585a5b46b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_b29c36f2-053d-4323-b87d-09fcf731df78" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_30d8b425-c54d-4db2-9265-71564c36b3ee" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_3064cbaf-0754-4a22-8405-93d585a5b46b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_30d8b425-c54d-4db2-9265-71564c36b3ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_435d63d8-574c-42a0-ab77-e372193083ff" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_3064cbaf-0754-4a22-8405-93d585a5b46b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_435d63d8-574c-42a0-ab77-e372193083ff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_0955280a-2205-4936-aec4-845cf8eb7901" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_3064cbaf-0754-4a22-8405-93d585a5b46b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_0955280a-2205-4936-aec4-845cf8eb7901" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_62c9a1a6-396d-467f-8d8a-e2a7d49d81e0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_3064cbaf-0754-4a22-8405-93d585a5b46b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_62c9a1a6-396d-467f-8d8a-e2a7d49d81e0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/AccruedLiabilitiesDetails" xlink:type="simple" xlink:href="shc-20210630.xsd#AccruedLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/AccruedLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_07513caf-1de2-42e7-b612-77294091f067" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedUtilitiesCurrent_41811b84-70f6-4bfb-ae44-14611ce6bd9c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedUtilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_07513caf-1de2-42e7-b612-77294091f067" xlink:to="loc_us-gaap_AccruedUtilitiesCurrent_41811b84-70f6-4bfb-ae44-14611ce6bd9c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilitiesCurrent_77610b9f-1d64-47af-bf19-25fc1dd72e69" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_07513caf-1de2-42e7-b612-77294091f067" xlink:to="loc_us-gaap_DerivativeLiabilitiesCurrent_77610b9f-1d64-47af-bf19-25fc1dd72e69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxesPayableCurrent_8b3b54dc-25d9-4278-a445-b4fa0e64e928" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TaxesPayableCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_07513caf-1de2-42e7-b612-77294091f067" xlink:to="loc_us-gaap_TaxesPayableCurrent_8b3b54dc-25d9-4278-a445-b4fa0e64e928" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_37bd7896-3c60-45b3-a1fe-aab45296184d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_07513caf-1de2-42e7-b612-77294091f067" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_37bd7896-3c60-45b3-a1fe-aab45296184d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_8d22a724-afbc-4c56-93f8-d34a09ae9697" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_07513caf-1de2-42e7-b612-77294091f067" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_8d22a724-afbc-4c56-93f8-d34a09ae9697" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationReserveCurrent_81d1486c-d8b8-47e6-8611-ee0523d60a79" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LitigationReserveCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_07513caf-1de2-42e7-b612-77294091f067" xlink:to="loc_us-gaap_LitigationReserveCurrent_81d1486c-d8b8-47e6-8611-ee0523d60a79" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_f5806871-3d7e-4092-901d-7e939fdf0deb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_07513caf-1de2-42e7-b612-77294091f067" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_f5806871-3d7e-4092-901d-7e939fdf0deb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedInsuranceCurrent_bf47951c-c780-4552-83a2-2e461f12c7d6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedInsuranceCurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_07513caf-1de2-42e7-b612-77294091f067" xlink:to="loc_us-gaap_AccruedInsuranceCurrent_bf47951c-c780-4552-83a2-2e461f12c7d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_AccruedInterestExpenseCurrent_4465deb0-c3ca-4d36-8a15-8bea665b8d55" xlink:href="shc-20210630.xsd#shc_AccruedInterestExpenseCurrent"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_07513caf-1de2-42e7-b612-77294091f067" xlink:to="loc_shc_AccruedInterestExpenseCurrent_4465deb0-c3ca-4d36-8a15-8bea665b8d55" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/LongTermDebtScheduleofDebtDetails" xlink:type="simple" xlink:href="shc-20210630.xsd#LongTermDebtScheduleofDebtDetails"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/LongTermDebtScheduleofDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_ca32c838-99df-4e37-8a70-74c5c7d4bc7a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_e1fcb5ab-9ce9-44a7-a9f0-4bd8d7070647" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_ca32c838-99df-4e37-8a70-74c5c7d4bc7a" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_e1fcb5ab-9ce9-44a7-a9f0-4bd8d7070647" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_7a15a74e-b812-4a3a-9751-027802784c1c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_ca32c838-99df-4e37-8a70-74c5c7d4bc7a" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_7a15a74e-b812-4a3a-9751-027802784c1c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/LongTermDebtAggregateMaturitiesDetails" xlink:type="simple" xlink:href="shc-20210630.xsd#LongTermDebtAggregateMaturitiesDetails"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/LongTermDebtAggregateMaturitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_eeb51665-813e-49b1-a350-2f5b399d838a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_b4498825-e095-472a-a7ad-05992b797d1e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_eeb51665-813e-49b1-a350-2f5b399d838a" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_b4498825-e095-472a-a7ad-05992b797d1e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_a0c94f5f-0ecd-4aff-8e7b-01038053b924" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_eeb51665-813e-49b1-a350-2f5b399d838a" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_a0c94f5f-0ecd-4aff-8e7b-01038053b924" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_LongTermDebtMaturityAfterYearFour_03b1790b-9e62-4902-848b-f272f53f345b" xlink:href="shc-20210630.xsd#shc_LongTermDebtMaturityAfterYearFour"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_eeb51665-813e-49b1-a350-2f5b399d838a" xlink:to="loc_shc_LongTermDebtMaturityAfterYearFour_03b1790b-9e62-4902-848b-f272f53f345b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_ad9ca436-6e6f-4ded-ad88-c8345429a849" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_eeb51665-813e-49b1-a350-2f5b399d838a" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_ad9ca436-6e6f-4ded-ad88-c8345429a849" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_954e28b7-e16b-47ac-8266-ec4806cdf4f3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_eeb51665-813e-49b1-a350-2f5b399d838a" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_954e28b7-e16b-47ac-8266-ec4806cdf4f3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_179ca31a-96a3-414f-a94f-0f24c11f4e66" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_eeb51665-813e-49b1-a350-2f5b399d838a" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_179ca31a-96a3-414f-a94f-0f24c11f4e66" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/EmployeeBenefitsNetPeriodicBenefitCostDetails" xlink:type="simple" xlink:href="shc-20210630.xsd#EmployeeBenefitsNetPeriodicBenefitCostDetails"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/EmployeeBenefitsNetPeriodicBenefitCostDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_ff6720e2-f78d-4230-a292-d70bdf5f874d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanServiceCost_c36addd2-9299-4881-9169-40cd72255ac4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanServiceCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_ff6720e2-f78d-4230-a292-d70bdf5f874d" xlink:to="loc_us-gaap_DefinedBenefitPlanServiceCost_c36addd2-9299-4881-9169-40cd72255ac4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_f1e5cd61-86ba-430f-8cba-051b03d49e40" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_ff6720e2-f78d-4230-a292-d70bdf5f874d" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_f1e5cd61-86ba-430f-8cba-051b03d49e40" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_88c5bd8c-b11b-419e-a1b7-a3816ac879b8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanInterestCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_ff6720e2-f78d-4230-a292-d70bdf5f874d" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_88c5bd8c-b11b-419e-a1b7-a3816ac879b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_8bc516f2-90bd-461e-89d5-c0f6bc3188ab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_ff6720e2-f78d-4230-a292-d70bdf5f874d" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_8bc516f2-90bd-461e-89d5-c0f6bc3188ab" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/OtherComprehensiveIncomeLossDetails" xlink:type="simple" xlink:href="shc-20210630.xsd#OtherComprehensiveIncomeLossDetails"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/OtherComprehensiveIncomeLossDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_b59bb7cb-0ef5-48bf-9e76-d0a9a7eb79a2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_ba6b5c7a-b83b-40ab-baad-ca3791f5130c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_b59bb7cb-0ef5-48bf-9e76-d0a9a7eb79a2" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_ba6b5c7a-b83b-40ab-baad-ca3791f5130c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_f418ded3-5f39-44a2-b483-449a03ef6e31" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_b59bb7cb-0ef5-48bf-9e76-d0a9a7eb79a2" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_f418ded3-5f39-44a2-b483-449a03ef6e31" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/EarningsPerShareDetails" xlink:type="simple" xlink:href="shc-20210630.xsd#EarningsPerShareDetails"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/EarningsPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_e33fc19f-f07c-407b-ab05-5da20251dcd4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_76470111-a36e-4f1f-9c71-ce82569b1ebc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_e33fc19f-f07c-407b-ab05-5da20251dcd4" xlink:to="loc_us-gaap_ProfitLoss_76470111-a36e-4f1f-9c71-ce82569b1ebc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesDiluted_8059f357-cfd8-4b20-946f-2449cee3a8f5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesDiluted"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_e33fc19f-f07c-407b-ab05-5da20251dcd4" xlink:to="loc_us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesDiluted_8059f357-cfd8-4b20-946f-2449cee3a8f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_03b74aa5-4deb-44b6-b7cc-eba3761b0ca7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_e33fc19f-f07c-407b-ab05-5da20251dcd4" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_03b74aa5-4deb-44b6-b7cc-eba3761b0ca7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_f1b0a64d-c7ef-4e29-8248-ffca05bb577f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesBasic_8e9e5ed6-43e8-4785-a43f-eecd696c272a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesBasic"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_f1b0a64d-c7ef-4e29-8248-ffca05bb577f" xlink:to="loc_us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesBasic_8e9e5ed6-43e8-4785-a43f-eecd696c272a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_dc9d2add-bdbc-4cb5-9cf9-33a6c011d9cf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_f1b0a64d-c7ef-4e29-8248-ffca05bb577f" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_dc9d2add-bdbc-4cb5-9cf9-33a6c011d9cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_b6d8c072-e6ed-4aab-9a95-2a1ef7ac7019" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_f1b0a64d-c7ef-4e29-8248-ffca05bb577f" xlink:to="loc_us-gaap_ProfitLoss_b6d8c072-e6ed-4aab-9a95-2a1ef7ac7019" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/SegmentInformationReconciliationofReportableSegmentAmountsDetails" xlink:type="simple" xlink:href="shc-20210630.xsd#SegmentInformationReconciliationofReportableSegmentAmountsDetails"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/SegmentInformationReconciliationofReportableSegmentAmountsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_4aa4a74d-85cc-4054-93bd-2800d287b7b0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetRetirementObligationAccretionExpense_6e3f797c-b1ef-4eb3-9106-8a0bcca01e5f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetRetirementObligationAccretionExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_4aa4a74d-85cc-4054-93bd-2800d287b7b0" xlink:to="loc_us-gaap_AssetRetirementObligationAccretionExpense_6e3f797c-b1ef-4eb3-9106-8a0bcca01e5f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_ForeignCurrencyGainLossAndGainLossOnEmbeddedDerivative_cd39dd10-bdb4-4d3d-90e8-29aae376b06c" xlink:href="shc-20210630.xsd#shc_ForeignCurrencyGainLossAndGainLossOnEmbeddedDerivative"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_4aa4a74d-85cc-4054-93bd-2800d287b7b0" xlink:to="loc_shc_ForeignCurrencyGainLossAndGainLossOnEmbeddedDerivative_cd39dd10-bdb4-4d3d-90e8-29aae376b06c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_CostAndExpensesCOVID19_7716b710-b70b-4630-941e-97f30b39c343" xlink:href="shc-20210630.xsd#shc_CostAndExpensesCOVID19"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_4aa4a74d-85cc-4054-93bd-2800d287b7b0" xlink:to="loc_shc_CostAndExpensesCOVID19_7716b710-b70b-4630-941e-97f30b39c343" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_SegmentIncomeLoss_bbda52a7-69bc-4222-9b03-f2fb5067fa37" xlink:href="shc-20210630.xsd#shc_SegmentIncomeLoss"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_4aa4a74d-85cc-4054-93bd-2800d287b7b0" xlink:to="loc_shc_SegmentIncomeLoss_bbda52a7-69bc-4222-9b03-f2fb5067fa37" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessExitCosts1_91d1b6c1-69fa-425c-91bf-84c663ccac03" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessExitCosts1"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_4aa4a74d-85cc-4054-93bd-2800d287b7b0" xlink:to="loc_us-gaap_BusinessExitCosts1_91d1b6c1-69fa-425c-91bf-84c663ccac03" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationSettlementExpense_69937e40-7db5-4707-8178-187911c69c0f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LitigationSettlementExpense"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_4aa4a74d-85cc-4054-93bd-2800d287b7b0" xlink:to="loc_us-gaap_LitigationSettlementExpense_69937e40-7db5-4707-8178-187911c69c0f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_604010e1-46d7-4272-827a-53bc535e8cdf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_4aa4a74d-85cc-4054-93bd-2800d287b7b0" xlink:to="loc_us-gaap_InterestExpense_604010e1-46d7-4272-827a-53bc535e8cdf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_548d3bce-a9c9-43ec-a75c-73e792b705a6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_4aa4a74d-85cc-4054-93bd-2800d287b7b0" xlink:to="loc_us-gaap_ShareBasedCompensation_548d3bce-a9c9-43ec-a75c-73e792b705a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_AcquisitionAndDivestitureRelatedChargesNet_c3635f2d-3e9f-4e9f-9543-7808928cfbde" xlink:href="shc-20210630.xsd#shc_AcquisitionAndDivestitureRelatedChargesNet"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_4aa4a74d-85cc-4054-93bd-2800d287b7b0" xlink:to="loc_shc_AcquisitionAndDivestitureRelatedChargesNet_c3635f2d-3e9f-4e9f-9543-7808928cfbde" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherRestructuringCosts_e671ebbc-1ce3-498b-b7a0-46fb62b00ebf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherRestructuringCosts"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_4aa4a74d-85cc-4054-93bd-2800d287b7b0" xlink:to="loc_us-gaap_OtherRestructuringCosts_e671ebbc-1ce3-498b-b7a0-46fb62b00ebf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_30948397-722f-4734-85ff-04fbc05d9ca0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_4aa4a74d-85cc-4054-93bd-2800d287b7b0" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_30948397-722f-4734-85ff-04fbc05d9ca0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_60ba6438-8cf0-454a-a92f-bfbe1e2370c2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_4aa4a74d-85cc-4054-93bd-2800d287b7b0" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_60ba6438-8cf0-454a-a92f-bfbe1e2370c2" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
