<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2024 Workiva-->
<!--r:b551826e-4642-40a5-8e0b-2a79b445257a,g:dcaf431e-567b-4473-a761-a56b0add0b82-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://soterahealth.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="shc-20240930.xsd#ConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_cea74d33-0db3-48c3-ae5e-2a3992387a6f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetRetirementObligationsNoncurrent_f35fd62c-3ae3-416b-8718-c290e3e0bc7b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetRetirementObligationsNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_cea74d33-0db3-48c3-ae5e-2a3992387a6f" xlink:to="loc_us-gaap_AssetRetirementObligationsNoncurrent_f35fd62c-3ae3-416b-8718-c290e3e0bc7b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_d23befed-5fb2-4ef3-b8cd-3f3f59515f63" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_cea74d33-0db3-48c3-ae5e-2a3992387a6f" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_d23befed-5fb2-4ef3-b8cd-3f3f59515f63" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRentCreditNoncurrent_7b6dfa84-1d86-4026-a5c9-d9a9a5eda1b2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredRentCreditNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_cea74d33-0db3-48c3-ae5e-2a3992387a6f" xlink:to="loc_us-gaap_DeferredRentCreditNoncurrent_7b6dfa84-1d86-4026-a5c9-d9a9a5eda1b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_4562b2af-cc16-451f-9f3d-4d8d6209ed35" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_cea74d33-0db3-48c3-ae5e-2a3992387a6f" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_4562b2af-cc16-451f-9f3d-4d8d6209ed35" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_7d3bdf80-c3c2-453a-a79d-23b518e57ce7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_cea74d33-0db3-48c3-ae5e-2a3992387a6f" xlink:to="loc_us-gaap_LiabilitiesCurrent_7d3bdf80-c3c2-453a-a79d-23b518e57ce7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_84def1f6-3c3d-4620-8363-55e3681aa60b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_cea74d33-0db3-48c3-ae5e-2a3992387a6f" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_84def1f6-3c3d-4620-8363-55e3681aa60b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionAndOtherPostretirementAndPostemploymentBenefitPlansLiabilitiesNoncurrent_d4747ef8-77b0-4a5c-94da-49b8427d97a4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PensionAndOtherPostretirementAndPostemploymentBenefitPlansLiabilitiesNoncurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_cea74d33-0db3-48c3-ae5e-2a3992387a6f" xlink:to="loc_us-gaap_PensionAndOtherPostretirementAndPostemploymentBenefitPlansLiabilitiesNoncurrent_d4747ef8-77b0-4a5c-94da-49b8427d97a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_4b4eaab9-3163-49a1-8bfb-aee4e0120c45" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_cea74d33-0db3-48c3-ae5e-2a3992387a6f" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_4b4eaab9-3163-49a1-8bfb-aee4e0120c45" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_79615fbe-2241-41c9-a783-b71b36944f39" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_cea74d33-0db3-48c3-ae5e-2a3992387a6f" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_79615fbe-2241-41c9-a783-b71b36944f39" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_c2ba12be-d349-4d75-b82d-d1e59cc1f5b3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_d1f39d51-cb4b-47f2-9e32-e5de9bcdcee2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_c2ba12be-d349-4d75-b82d-d1e59cc1f5b3" xlink:to="loc_us-gaap_Liabilities_d1f39d51-cb4b-47f2-9e32-e5de9bcdcee2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_eff854a6-674b-4ff7-b3a6-5af4457727db" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_c2ba12be-d349-4d75-b82d-d1e59cc1f5b3" xlink:to="loc_us-gaap_CommitmentsAndContingencies_eff854a6-674b-4ff7-b3a6-5af4457727db" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_9a5fd615-ff6c-41e9-b956-f087234e4c18" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_c2ba12be-d349-4d75-b82d-d1e59cc1f5b3" xlink:to="loc_us-gaap_StockholdersEquity_9a5fd615-ff6c-41e9-b956-f087234e4c18" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_bd00339a-8bda-4594-b414-8b60f68b73ae" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_537abc20-1a44-403d-b1db-6d80c08ee684" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_bd00339a-8bda-4594-b414-8b60f68b73ae" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_537abc20-1a44-403d-b1db-6d80c08ee684" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_a2d5e95c-0dc0-48e0-846b-dabd9500fc4e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_bd00339a-8bda-4594-b414-8b60f68b73ae" xlink:to="loc_us-gaap_CommonStockValue_a2d5e95c-0dc0-48e0-846b-dabd9500fc4e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_41c23d65-8fb8-4b24-90c8-3756b7b1b8b6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_bd00339a-8bda-4594-b414-8b60f68b73ae" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_41c23d65-8fb8-4b24-90c8-3756b7b1b8b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_45dea6be-2b88-4fd8-8360-e67c7622263a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_bd00339a-8bda-4594-b414-8b60f68b73ae" xlink:to="loc_us-gaap_PreferredStockValue_45dea6be-2b88-4fd8-8360-e67c7622263a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonValue_2a164e13-0a4a-4d60-91dd-56c147a309bb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TreasuryStockCommonValue"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_bd00339a-8bda-4594-b414-8b60f68b73ae" xlink:to="loc_us-gaap_TreasuryStockCommonValue_2a164e13-0a4a-4d60-91dd-56c147a309bb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_c8939689-b663-4eb3-97e4-e00dc779bdb3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_bd00339a-8bda-4594-b414-8b60f68b73ae" xlink:to="loc_us-gaap_AdditionalPaidInCapital_c8939689-b663-4eb3-97e4-e00dc779bdb3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_1a07f0c7-f225-4967-bbc8-9a908256a273" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_ebac85db-962a-470b-bcd8-cf8c2e775cdf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_1a07f0c7-f225-4967-bbc8-9a908256a273" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_ebac85db-962a-470b-bcd8-cf8c2e775cdf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_619bfd52-29c9-4f33-aa2a-d6cce616980f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_1a07f0c7-f225-4967-bbc8-9a908256a273" xlink:to="loc_us-gaap_AccountsPayableCurrent_619bfd52-29c9-4f33-aa2a-d6cce616980f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityCurrent_73a4165e-25e9-4b85-a34f-9f24641869a9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FinanceLeaseLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_1a07f0c7-f225-4967-bbc8-9a908256a273" xlink:to="loc_us-gaap_FinanceLeaseLiabilityCurrent_73a4165e-25e9-4b85-a34f-9f24641869a9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_74d58913-e6c0-4d5f-89d5-97f0df99ca58" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_1a07f0c7-f225-4967-bbc8-9a908256a273" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_74d58913-e6c0-4d5f-89d5-97f0df99ca58" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_534a3fb9-3d69-405e-937a-30256465adff" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_1a07f0c7-f225-4967-bbc8-9a908256a273" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_534a3fb9-3d69-405e-937a-30256465adff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_c4c7f1d0-cd78-41d2-ba50-ad496eb024e6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedIncomeTaxesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_1a07f0c7-f225-4967-bbc8-9a908256a273" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_c4c7f1d0-cd78-41d2-ba50-ad496eb024e6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_ac18b32b-1080-42f2-9473-be02d702ba9e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_1a07f0c7-f225-4967-bbc8-9a908256a273" xlink:to="loc_us-gaap_LongTermDebtCurrent_ac18b32b-1080-42f2-9473-be02d702ba9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_75fa6eb9-60a1-4284-a47b-e350c79de8de" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashCurrent_12932598-5c98-4f7d-91e0-abc8dcf438d0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RestrictedCashCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_75fa6eb9-60a1-4284-a47b-e350c79de8de" xlink:to="loc_us-gaap_RestrictedCashCurrent_12932598-5c98-4f7d-91e0-abc8dcf438d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_a7301db3-5730-44f9-82af-9f05c614c48e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_75fa6eb9-60a1-4284-a47b-e350c79de8de" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_a7301db3-5730-44f9-82af-9f05c614c48e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_42295978-43be-4391-b125-be5c2607ed78" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_75fa6eb9-60a1-4284-a47b-e350c79de8de" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_42295978-43be-4391-b125-be5c2607ed78" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_839d3c0b-91e9-4681-9383-5f1c0a7accce" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_75fa6eb9-60a1-4284-a47b-e350c79de8de" xlink:to="loc_us-gaap_InventoryNet_839d3c0b-91e9-4681-9383-5f1c0a7accce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_0f2fe6b4-63c9-4702-a9b3-d080c2cecdc9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_75fa6eb9-60a1-4284-a47b-e350c79de8de" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_0f2fe6b4-63c9-4702-a9b3-d080c2cecdc9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxesReceivable_cdeacf4e-97ed-4b13-b118-b7e30014c8f1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeTaxesReceivable"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_75fa6eb9-60a1-4284-a47b-e350c79de8de" xlink:to="loc_us-gaap_IncomeTaxesReceivable_cdeacf4e-97ed-4b13-b118-b7e30014c8f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_cc4dc84a-54c1-45f8-830c-3292d3572a1b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAssetsForPlanBenefitsNoncurrent_572c0952-9844-4795-bd37-62e7ec350dd8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanAssetsForPlanBenefitsNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_cc4dc84a-54c1-45f8-830c-3292d3572a1b" xlink:to="loc_us-gaap_DefinedBenefitPlanAssetsForPlanBenefitsNoncurrent_572c0952-9844-4795-bd37-62e7ec350dd8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_81174efa-b7a4-46ba-a24d-2d20e703f061" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_cc4dc84a-54c1-45f8-830c-3292d3572a1b" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_81174efa-b7a4-46ba-a24d-2d20e703f061" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_73a42749-aaba-441f-b5c1-e91e79b879dc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_cc4dc84a-54c1-45f8-830c-3292d3572a1b" xlink:to="loc_us-gaap_Goodwill_73a42749-aaba-441f-b5c1-e91e79b879dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_61d8a553-01a1-4f46-81ea-e147926dda01" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_cc4dc84a-54c1-45f8-830c-3292d3572a1b" xlink:to="loc_us-gaap_AssetsCurrent_61d8a553-01a1-4f46-81ea-e147926dda01" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_6293fe2c-8f01-43df-8a07-a0b9a03a1182" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_cc4dc84a-54c1-45f8-830c-3292d3572a1b" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_6293fe2c-8f01-43df-8a07-a0b9a03a1182" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_33a737cb-a334-46bf-addf-caae76dca5c0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_cc4dc84a-54c1-45f8-830c-3292d3572a1b" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_33a737cb-a334-46bf-addf-caae76dca5c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_65f89921-99e4-43c5-8f7c-e928570a7346" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_cc4dc84a-54c1-45f8-830c-3292d3572a1b" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_65f89921-99e4-43c5-8f7c-e928570a7346" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_02aded42-15a1-45fa-9ab1-1191fbab8ff3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_cc4dc84a-54c1-45f8-830c-3292d3572a1b" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_02aded42-15a1-45fa-9ab1-1191fbab8ff3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/ConsolidatedStatementsofOperationsandComprehensiveIncomeLoss" xlink:type="simple" xlink:href="shc-20240930.xsd#ConsolidatedStatementsofOperationsandComprehensiveIncomeLoss"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/ConsolidatedStatementsofOperationsandComprehensiveIncomeLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_04f75135-00c4-45f7-9dfa-79a80b34583e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_c127d821-6fe7-450b-bee9-e39df3c3912a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_04f75135-00c4-45f7-9dfa-79a80b34583e" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_c127d821-6fe7-450b-bee9-e39df3c3912a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_00e44bc1-9694-44c0-a013-3e2621e3250b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_04f75135-00c4-45f7-9dfa-79a80b34583e" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_00e44bc1-9694-44c0-a013-3e2621e3250b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_e17966c4-045e-4278-96f1-3d5be1fd0699" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_04f75135-00c4-45f7-9dfa-79a80b34583e" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_e17966c4-045e-4278-96f1-3d5be1fd0699" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_050a5880-58c7-4a80-ac73-b1442a24dd6b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_04f75135-00c4-45f7-9dfa-79a80b34583e" xlink:to="loc_us-gaap_NetIncomeLoss_050a5880-58c7-4a80-ac73-b1442a24dd6b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_b54157f3-1234-4424-a51b-f97c52319a1d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_8aec7c85-8ed5-4e29-a1b2-3b438becfa82" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_b54157f3-1234-4424-a51b-f97c52319a1d" xlink:to="loc_us-gaap_OperatingIncomeLoss_8aec7c85-8ed5-4e29-a1b2-3b438becfa82" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_8a64f8f1-1aed-4e72-ae8e-a6c0833d56d5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_b54157f3-1234-4424-a51b-f97c52319a1d" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_8a64f8f1-1aed-4e72-ae8e-a6c0833d56d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_a4674cd7-9fcd-4f13-8427-a6abc90fdc40" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_b54157f3-1234-4424-a51b-f97c52319a1d" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_a4674cd7-9fcd-4f13-8427-a6abc90fdc40" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_a561a031-8bae-4033-805a-0bc34dea615a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_b54157f3-1234-4424-a51b-f97c52319a1d" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_a561a031-8bae-4033-805a-0bc34dea615a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_GainLossOnRefinancingOfDebt_4025b3eb-6f4d-40ef-b9fa-4c0850ecc5a0" xlink:href="shc-20240930.xsd#shc_GainLossOnRefinancingOfDebt"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_b54157f3-1234-4424-a51b-f97c52319a1d" xlink:to="loc_shc_GainLossOnRefinancingOfDebt_4025b3eb-6f4d-40ef-b9fa-4c0850ecc5a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_LitigationSettlementNonoperatingExpense_bc13d0ee-5ea3-4de2-b4c9-e428dc72cee9" xlink:href="shc-20240930.xsd#shc_LitigationSettlementNonoperatingExpense"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_b54157f3-1234-4424-a51b-f97c52319a1d" xlink:to="loc_shc_LitigationSettlementNonoperatingExpense_bc13d0ee-5ea3-4de2-b4c9-e428dc72cee9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_05b0b7e2-4006-400f-8891-5ac8933fc6ab" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_34f612f6-b0d1-4b7c-bd2f-6fc137701ab9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_05b0b7e2-4006-400f-8891-5ac8933fc6ab" xlink:to="loc_us-gaap_OperatingExpenses_34f612f6-b0d1-4b7c-bd2f-6fc137701ab9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_8efade02-a075-44bb-9063-4a6524ffa01c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_05b0b7e2-4006-400f-8891-5ac8933fc6ab" xlink:to="loc_us-gaap_GrossProfit_8efade02-a075-44bb-9063-4a6524ffa01c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_09dab722-b76e-476e-9443-d38cb56192eb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_c219e7ea-f506-4d88-8163-b0012861789b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_09dab722-b76e-476e-9443-d38cb56192eb" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_c219e7ea-f506-4d88-8163-b0012861789b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_c0cea0d7-8f50-4856-95e0-bb1d77448368" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_09dab722-b76e-476e-9443-d38cb56192eb" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_c0cea0d7-8f50-4856-95e0-bb1d77448368" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_eba29aad-aa95-4314-955f-802aa261fb18" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_ee80cde9-1b06-44ff-a21d-319c8f16c046" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_eba29aad-aa95-4314-955f-802aa261fb18" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_ee80cde9-1b06-44ff-a21d-319c8f16c046" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_AmortizationOfIntangibleAssetsNonproduction_1a9e6135-e0c2-42cd-ba48-0b00ff0a840d" xlink:href="shc-20240930.xsd#shc_AmortizationOfIntangibleAssetsNonproduction"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_eba29aad-aa95-4314-955f-802aa261fb18" xlink:to="loc_shc_AmortizationOfIntangibleAssetsNonproduction_1a9e6135-e0c2-42cd-ba48-0b00ff0a840d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_6421fb04-d107-4ed7-b2f3-b3d0b7a90c72" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_dbe316f2-cb90-4f6c-a9a6-198eb80c1973" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CostOfRevenue"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_6421fb04-d107-4ed7-b2f3-b3d0b7a90c72" xlink:to="loc_us-gaap_CostOfRevenue_dbe316f2-cb90-4f6c-a9a6-198eb80c1973" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_3af5b257-3243-4265-9041-371bfd91305e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_6421fb04-d107-4ed7-b2f3-b3d0b7a90c72" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_3af5b257-3243-4265-9041-371bfd91305e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/ConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="shc-20240930.xsd#ConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/ConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_08a3305d-425b-418a-aa4f-52c8d15b525b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_8d95a31e-aa45-4018-8d15-dff8c4c2bfc8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_08a3305d-425b-418a-aa4f-52c8d15b525b" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_8d95a31e-aa45-4018-8d15-dff8c4c2bfc8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_PaymentsOfDebtIssuanceCostsAndDebtDiscount_51bdd276-42b4-4cbf-882f-32688156f149" xlink:href="shc-20240930.xsd#shc_PaymentsOfDebtIssuanceCostsAndDebtDiscount"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_08a3305d-425b-418a-aa4f-52c8d15b525b" xlink:to="loc_shc_PaymentsOfDebtIssuanceCostsAndDebtDiscount_51bdd276-42b4-4cbf-882f-32688156f149" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_8d95ec70-54ef-45b3-b958-dfb126a9ea30" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_08a3305d-425b-418a-aa4f-52c8d15b525b" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_8d95ec70-54ef-45b3-b958-dfb126a9ea30" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_BuyoutOfLeasedFacility_7497cbaa-04c8-4720-94c5-efc166523d90" xlink:href="shc-20240930.xsd#shc_BuyoutOfLeasedFacility"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_08a3305d-425b-418a-aa4f-52c8d15b525b" xlink:to="loc_shc_BuyoutOfLeasedFacility_7497cbaa-04c8-4720-94c5-efc166523d90" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLinesOfCredit_9e1394a8-8157-4065-9090-ef28ea1855da" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RepaymentsOfLinesOfCredit"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_08a3305d-425b-418a-aa4f-52c8d15b525b" xlink:to="loc_us-gaap_RepaymentsOfLinesOfCredit_9e1394a8-8157-4065-9090-ef28ea1855da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_8086c5c0-a352-4ace-9f47-c9271f35ae26" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_08a3305d-425b-418a-aa4f-52c8d15b525b" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_8086c5c0-a352-4ace-9f47-c9271f35ae26" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_355cae88-7ecc-4ffd-b709-a955e0bc06bc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossRelatedToLitigationSettlement_1bbbbeb7-8fcd-46a7-a455-8cd92838d004" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GainLossRelatedToLitigationSettlement"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_355cae88-7ecc-4ffd-b709-a955e0bc06bc" xlink:to="loc_us-gaap_GainLossRelatedToLitigationSettlement_1bbbbeb7-8fcd-46a7-a455-8cd92838d004" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetRetirementObligationAccretionExpense_43058b87-7f1f-4200-9487-3fc6dac8856a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetRetirementObligationAccretionExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_355cae88-7ecc-4ffd-b709-a955e0bc06bc" xlink:to="loc_us-gaap_AssetRetirementObligationAccretionExpense_43058b87-7f1f-4200-9487-3fc6dac8856a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_efff214d-a421-465d-b20b-67d748b0f288" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_355cae88-7ecc-4ffd-b709-a955e0bc06bc" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_efff214d-a421-465d-b20b-67d748b0f288" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_5fdecdc6-d7a8-4fab-baa2-ab641bb5922c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_355cae88-7ecc-4ffd-b709-a955e0bc06bc" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_5fdecdc6-d7a8-4fab-baa2-ab641bb5922c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_f986cc69-0096-4ba4-b823-045a229a85d9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_355cae88-7ecc-4ffd-b709-a955e0bc06bc" xlink:to="loc_us-gaap_Depreciation_f986cc69-0096-4ba4-b823-045a229a85d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_c14540b4-0abf-4f50-86df-99689b0e3f0c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_355cae88-7ecc-4ffd-b709-a955e0bc06bc" xlink:to="loc_us-gaap_NetIncomeLoss_c14540b4-0abf-4f50-86df-99689b0e3f0c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_b95cc2e0-4ea2-4418-af9c-831757123f29" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_355cae88-7ecc-4ffd-b709-a955e0bc06bc" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_b95cc2e0-4ea2-4418-af9c-831757123f29" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_80b6d942-2af1-4615-a027-6bdb7e40ae1a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_355cae88-7ecc-4ffd-b709-a955e0bc06bc" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_80b6d942-2af1-4615-a027-6bdb7e40ae1a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_764f922c-47bc-41a5-a6ec-8cb8b7f762b3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_355cae88-7ecc-4ffd-b709-a955e0bc06bc" xlink:to="loc_us-gaap_ShareBasedCompensation_764f922c-47bc-41a5-a6ec-8cb8b7f762b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_738fd162-6428-4113-af40-90a8dc6c0ebd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_355cae88-7ecc-4ffd-b709-a955e0bc06bc" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_738fd162-6428-4113-af40-90a8dc6c0ebd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrealizedGainLossOnDerivatives_9336ffaf-9d16-4793-84a2-79c94c9ee033" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_UnrealizedGainLossOnDerivatives"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_355cae88-7ecc-4ffd-b709-a955e0bc06bc" xlink:to="loc_us-gaap_UnrealizedGainLossOnDerivatives_9336ffaf-9d16-4793-84a2-79c94c9ee033" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_3025f1cb-38af-4f2c-8203-93edd40e8e1f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_355cae88-7ecc-4ffd-b709-a955e0bc06bc" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_3025f1cb-38af-4f2c-8203-93edd40e8e1f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_2222436d-b027-4ffc-9e32-2757c0aaaa4d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_355cae88-7ecc-4ffd-b709-a955e0bc06bc" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_2222436d-b027-4ffc-9e32-2757c0aaaa4d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_bb109b64-fa8b-48be-8da5-a054290064da" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_355cae88-7ecc-4ffd-b709-a955e0bc06bc" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_bb109b64-fa8b-48be-8da5-a054290064da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossUnrealized_31e38a4a-b3ec-4313-85af-463b4d6beca2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ForeignCurrencyTransactionGainLossUnrealized"/>
    <link:calculationArc order="15" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_355cae88-7ecc-4ffd-b709-a955e0bc06bc" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossUnrealized_31e38a4a-b3ec-4313-85af-463b4d6beca2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_a83990a0-0659-4e73-a075-6f5982e319bd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_355cae88-7ecc-4ffd-b709-a955e0bc06bc" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_a83990a0-0659-4e73-a075-6f5982e319bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherCurrentAssets_c8de0778-887d-4f72-9183-0aebf8e3d271" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInOtherCurrentAssets"/>
    <link:calculationArc order="17" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_355cae88-7ecc-4ffd-b709-a955e0bc06bc" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherCurrentAssets_c8de0778-887d-4f72-9183-0aebf8e3d271" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_9419987e-a89d-4b58-8576-58215a24770d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="18" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_355cae88-7ecc-4ffd-b709-a955e0bc06bc" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_9419987e-a89d-4b58-8576-58215a24770d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_dde2d9c1-c1c5-4ac2-8cd2-0f8e418bb28c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable"/>
    <link:calculationArc order="19" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_355cae88-7ecc-4ffd-b709-a955e0bc06bc" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_dde2d9c1-c1c5-4ac2-8cd2-0f8e418bb28c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_GainLossOnRefinancingOfDebt_8b26b85e-82d6-498d-9dc9-0916e68ec3c0" xlink:href="shc-20240930.xsd#shc_GainLossOnRefinancingOfDebt"/>
    <link:calculationArc order="20" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_355cae88-7ecc-4ffd-b709-a955e0bc06bc" xlink:to="loc_shc_GainLossOnRefinancingOfDebt_8b26b85e-82d6-498d-9dc9-0916e68ec3c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_2c005f56-2fde-42a6-91e7-19244bcac804" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_0e5738d8-5517-4ef9-a0da-827e5f2b0c28" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_2c005f56-2fde-42a6-91e7-19244bcac804" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_0e5738d8-5517-4ef9-a0da-827e5f2b0c28" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_44b52745-5dd9-4f6e-a6f0-487b144111f6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_2c005f56-2fde-42a6-91e7-19244bcac804" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_44b52745-5dd9-4f6e-a6f0-487b144111f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f6a255e7-a278-46d9-927d-5f11cb0dae13" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_2c005f56-2fde-42a6-91e7-19244bcac804" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f6a255e7-a278-46d9-927d-5f11cb0dae13" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_01bfd04d-be7f-4312-8ea7-261622da1597" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_2c005f56-2fde-42a6-91e7-19244bcac804" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_01bfd04d-be7f-4312-8ea7-261622da1597" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d2b914e6-8b94-43e0-9386-ba933030535d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_fef9df93-94f3-426a-b6af-98106135dce7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d2b914e6-8b94-43e0-9386-ba933030535d" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_fef9df93-94f3-426a-b6af-98106135dce7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_994131a8-6fdb-49f7-af69-551f6f0dacf3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d2b914e6-8b94-43e0-9386-ba933030535d" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_994131a8-6fdb-49f7-af69-551f6f0dacf3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/InventoriesDetails" xlink:type="simple" xlink:href="shc-20240930.xsd#InventoriesDetails"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/InventoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryGross_48692f98-422d-4c80-b68b-bbf4ded1542a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoods_b26750f0-9af9-4105-8881-7e354cca9193" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryFinishedGoods"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryGross_48692f98-422d-4c80-b68b-bbf4ded1542a" xlink:to="loc_us-gaap_InventoryFinishedGoods_b26750f0-9af9-4105-8881-7e354cca9193" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcess_e0a94200-2a4e-4dea-95d0-5090088eb963" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryWorkInProcess"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryGross_48692f98-422d-4c80-b68b-bbf4ded1542a" xlink:to="loc_us-gaap_InventoryWorkInProcess_e0a94200-2a4e-4dea-95d0-5090088eb963" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsAndSupplies_5554bb65-98f4-42b5-af65-5c46c6abc6aa" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryRawMaterialsAndSupplies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryGross_48692f98-422d-4c80-b68b-bbf4ded1542a" xlink:to="loc_us-gaap_InventoryRawMaterialsAndSupplies_5554bb65-98f4-42b5-af65-5c46c6abc6aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_e65e1112-f430-4b4b-9b82-5251d84117b3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryGross_d34ed3a1-ef65-4405-b053-bc4ca00af7d0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_e65e1112-f430-4b4b-9b82-5251d84117b3" xlink:to="loc_us-gaap_InventoryGross_d34ed3a1-ef65-4405-b053-bc4ca00af7d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryAdjustments_96408f06-bc8a-49a5-9049-8f708208caab" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryAdjustments"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_e65e1112-f430-4b4b-9b82-5251d84117b3" xlink:to="loc_us-gaap_InventoryAdjustments_96408f06-bc8a-49a5-9049-8f708208caab" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/PrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="simple" xlink:href="shc-20240930.xsd#PrepaidExpensesandOtherCurrentAssetsDetails"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/PrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_d1324a71-40a6-475d-b021-93ae060af86e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValueAddedTaxReceivableCurrent_f72c1ba9-26dd-422e-bfb6-6643c69742a6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ValueAddedTaxReceivableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_d1324a71-40a6-475d-b021-93ae060af86e" xlink:to="loc_us-gaap_ValueAddedTaxReceivableCurrent_f72c1ba9-26dd-422e-bfb6-6643c69742a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_PrepaidSoftwareLicensingCurrent_a294bccb-c613-49ac-99f4-18e0ac12c8c0" xlink:href="shc-20240930.xsd#shc_PrepaidSoftwareLicensingCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_d1324a71-40a6-475d-b021-93ae060af86e" xlink:to="loc_shc_PrepaidSoftwareLicensingCurrent_a294bccb-c613-49ac-99f4-18e0ac12c8c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidInsurance_66faaad4-9613-4b8e-8447-3b229e1ee696" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PrepaidInsurance"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_d1324a71-40a6-475d-b021-93ae060af86e" xlink:to="loc_us-gaap_PrepaidInsurance_66faaad4-9613-4b8e-8447-3b229e1ee696" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidRent_66dab098-c329-474c-ab79-6814684a5af9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PrepaidRent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_d1324a71-40a6-475d-b021-93ae060af86e" xlink:to="loc_us-gaap_PrepaidRent_66dab098-c329-474c-ab79-6814684a5af9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetNetCurrent_f4a9e3e5-bfd1-4980-a977-095167243cd4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ContractWithCustomerAssetNetCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_d1324a71-40a6-475d-b021-93ae060af86e" xlink:to="loc_us-gaap_ContractWithCustomerAssetNetCurrent_f4a9e3e5-bfd1-4980-a977-095167243cd4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidTaxes_84829355-df92-42d1-a459-8afc13d7745c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PrepaidTaxes"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_d1324a71-40a6-475d-b021-93ae060af86e" xlink:to="loc_us-gaap_PrepaidTaxes_84829355-df92-42d1-a459-8afc13d7745c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_PrepaidMaintenanceContractsCurrent_fb8b142a-7cf2-413e-acec-42677a9c1b05" xlink:href="shc-20240930.xsd#shc_PrepaidMaintenanceContractsCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_d1324a71-40a6-475d-b021-93ae060af86e" xlink:to="loc_shc_PrepaidMaintenanceContractsCurrent_fb8b142a-7cf2-413e-acec-42677a9c1b05" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Supplies_a1ba2dff-14b8-43cc-baa5-ea60de08bf73" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Supplies"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_d1324a71-40a6-475d-b021-93ae060af86e" xlink:to="loc_us-gaap_Supplies_a1ba2dff-14b8-43cc-baa5-ea60de08bf73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_52f291fc-e4a1-431f-a895-6dbcfd741b9b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_d1324a71-40a6-475d-b021-93ae060af86e" xlink:to="loc_us-gaap_OtherAssetsCurrent_52f291fc-e4a1-431f-a895-6dbcfd741b9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositsAssetsCurrent_754485be-eee0-4984-8f93-628fc93ae54c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DepositsAssetsCurrent"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_d1324a71-40a6-475d-b021-93ae060af86e" xlink:to="loc_us-gaap_DepositsAssetsCurrent_754485be-eee0-4984-8f93-628fc93ae54c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeAsset_90d519a4-35f7-433d-9667-78d773caf05b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeAsset"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_d1324a71-40a6-475d-b021-93ae060af86e" xlink:to="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeAsset_90d519a4-35f7-433d-9667-78d773caf05b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/GoodwillandOtherIntangibleAssetsScheduleofAcquiredFiniteLivedandIndefiniteLivedIntangibleAssetsDetails" xlink:type="simple" xlink:href="shc-20240930.xsd#GoodwillandOtherIntangibleAssetsScheduleofAcquiredFiniteLivedandIndefiniteLivedIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/GoodwillandOtherIntangibleAssetsScheduleofAcquiredFiniteLivedandIndefiniteLivedIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_4864d4f7-c31d-4293-9c73-8f9a71fd04e0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_582d924b-24f6-4ec0-ad19-ced64dd0f3a3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_4864d4f7-c31d-4293-9c73-8f9a71fd04e0" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_582d924b-24f6-4ec0-ad19-ced64dd0f3a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_35b7ddb3-bcf0-4ac9-9e45-078106f5272f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_4864d4f7-c31d-4293-9c73-8f9a71fd04e0" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_35b7ddb3-bcf0-4ac9-9e45-078106f5272f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/GoodwillandOtherIntangibleAssetsScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseDetails" xlink:type="simple" xlink:href="shc-20240930.xsd#GoodwillandOtherIntangibleAssetsScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseDetails"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/GoodwillandOtherIntangibleAssetsScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_3ca7e83a-7440-4f9c-aa77-ddc1cc3d391c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour_35c9042e-e135-45dd-9cf7-2486492084be" xlink:href="shc-20240930.xsd#shc_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_3ca7e83a-7440-4f9c-aa77-ddc1cc3d391c" xlink:to="loc_shc_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour_35c9042e-e135-45dd-9cf7-2486492084be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_d717554c-e744-43de-9fca-4e179dfe68a9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_3ca7e83a-7440-4f9c-aa77-ddc1cc3d391c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_d717554c-e744-43de-9fca-4e179dfe68a9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_5deaebe7-74e9-449b-859d-92cbd9658603" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_3ca7e83a-7440-4f9c-aa77-ddc1cc3d391c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_5deaebe7-74e9-449b-859d-92cbd9658603" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_eab4aa0e-6e53-451d-be7b-9aadeb6173a4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_3ca7e83a-7440-4f9c-aa77-ddc1cc3d391c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_eab4aa0e-6e53-451d-be7b-9aadeb6173a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_6efa69d9-7be8-460d-8a9f-a203f00c2baf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_3ca7e83a-7440-4f9c-aa77-ddc1cc3d391c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_6efa69d9-7be8-460d-8a9f-a203f00c2baf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_00c67d0d-93a6-446c-a662-c205754e5d84" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_3ca7e83a-7440-4f9c-aa77-ddc1cc3d391c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_00c67d0d-93a6-446c-a662-c205754e5d84" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/AccruedLiabilitiesDetails" xlink:type="simple" xlink:href="shc-20240930.xsd#AccruedLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/AccruedLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_36263441-785f-4970-bfec-046912ad43bb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedUtilitiesCurrent_3f8df835-9143-47c9-9247-ff954a6cf915" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedUtilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_36263441-785f-4970-bfec-046912ad43bb" xlink:to="loc_us-gaap_AccruedUtilitiesCurrent_3f8df835-9143-47c9-9247-ff954a6cf915" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilitiesCurrent_65df0f1d-9431-4251-9d53-fd9bf08f53d6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_36263441-785f-4970-bfec-046912ad43bb" xlink:to="loc_us-gaap_DerivativeLiabilitiesCurrent_65df0f1d-9431-4251-9d53-fd9bf08f53d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxesPayableCurrent_f0b07f4f-fd85-4b1f-9648-39d323d0df4d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TaxesPayableCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_36263441-785f-4970-bfec-046912ad43bb" xlink:to="loc_us-gaap_TaxesPayableCurrent_f0b07f4f-fd85-4b1f-9648-39d323d0df4d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_78725b3d-8bce-4201-a6e6-1d0a72a86daf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_36263441-785f-4970-bfec-046912ad43bb" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_78725b3d-8bce-4201-a6e6-1d0a72a86daf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_e80fe1c9-c2e6-42dc-ac92-83e68c844d0b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_36263441-785f-4970-bfec-046912ad43bb" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_e80fe1c9-c2e6-42dc-ac92-83e68c844d0b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationReserveCurrent_e48d5725-969a-4102-96a7-3b6e66f5f977" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LitigationReserveCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_36263441-785f-4970-bfec-046912ad43bb" xlink:to="loc_us-gaap_LitigationReserveCurrent_e48d5725-969a-4102-96a7-3b6e66f5f977" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_2e876ab7-0e50-4249-ad1a-840fe132c1fd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_36263441-785f-4970-bfec-046912ad43bb" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_2e876ab7-0e50-4249-ad1a-840fe132c1fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedInsuranceCurrent_4ca05529-9f32-4fe7-8035-9cfe7f5447c3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedInsuranceCurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_36263441-785f-4970-bfec-046912ad43bb" xlink:to="loc_us-gaap_AccruedInsuranceCurrent_4ca05529-9f32-4fe7-8035-9cfe7f5447c3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_AccruedInterestExpenseCurrent_b0b5c3b0-9462-4403-8632-b4d4a7aaa675" xlink:href="shc-20240930.xsd#shc_AccruedInterestExpenseCurrent"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_36263441-785f-4970-bfec-046912ad43bb" xlink:to="loc_shc_AccruedInterestExpenseCurrent_b0b5c3b0-9462-4403-8632-b4d4a7aaa675" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_LitigationSettlementReserveCurrent_383823c9-22ae-42db-8b62-062523d5244f" xlink:href="shc-20240930.xsd#shc_LitigationSettlementReserveCurrent"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_36263441-785f-4970-bfec-046912ad43bb" xlink:to="loc_shc_LitigationSettlementReserveCurrent_383823c9-22ae-42db-8b62-062523d5244f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/LongTermDebtScheduleofLongtermDebtInstrumentsDetails" xlink:type="simple" xlink:href="shc-20240930.xsd#LongTermDebtScheduleofLongtermDebtInstrumentsDetails"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/LongTermDebtScheduleofLongtermDebtInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_3d584821-e12c-4a85-9e83-432285607fb9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_5742f406-b0bf-4eef-a34a-07ed91a49a63" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentUnamortizedDiscount"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_3d584821-e12c-4a85-9e83-432285607fb9" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_5742f406-b0bf-4eef-a34a-07ed91a49a63" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_4ff1e387-3ae5-4c1b-8aed-5e8312340eed" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_3d584821-e12c-4a85-9e83-432285607fb9" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_4ff1e387-3ae5-4c1b-8aed-5e8312340eed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_LongTermDebtGrossNoncurrent_bd9b8aae-ee8e-419a-ad2f-fec56f88f097" xlink:href="shc-20240930.xsd#shc_LongTermDebtGrossNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_3d584821-e12c-4a85-9e83-432285607fb9" xlink:to="loc_shc_LongTermDebtGrossNoncurrent_bd9b8aae-ee8e-419a-ad2f-fec56f88f097" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_f7912d8b-3ae6-47fc-83b1-a9bac3bd97d2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_bad23e46-66de-48b8-9a5b-dba69de669f7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_f7912d8b-3ae6-47fc-83b1-a9bac3bd97d2" xlink:to="loc_us-gaap_LongTermDebtCurrent_bad23e46-66de-48b8-9a5b-dba69de669f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_8c7fb5e1-1a83-4509-882f-c03a0c382c47" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_f7912d8b-3ae6-47fc-83b1-a9bac3bd97d2" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_8c7fb5e1-1a83-4509-882f-c03a0c382c47" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_f88fab21-a5ea-4f26-89d0-a0f19b037915" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_LongTermDebtCurrentMaturitiesGross_aa671f9c-8aff-4243-87a2-d605d4eb23a1" xlink:href="shc-20240930.xsd#shc_LongTermDebtCurrentMaturitiesGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtCurrent_f88fab21-a5ea-4f26-89d0-a0f19b037915" xlink:to="loc_shc_LongTermDebtCurrentMaturitiesGross_aa671f9c-8aff-4243-87a2-d605d4eb23a1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountCurrent_c381dcbe-b3e7-4fe5-9e84-a5e2f12075fd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentUnamortizedDiscountCurrent"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtCurrent_f88fab21-a5ea-4f26-89d0-a0f19b037915" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountCurrent_c381dcbe-b3e7-4fe5-9e84-a5e2f12075fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsCurrentNet_9b4647ae-6e87-4cf7-a842-1d4d0712b27f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredFinanceCostsCurrentNet"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtCurrent_f88fab21-a5ea-4f26-89d0-a0f19b037915" xlink:to="loc_us-gaap_DeferredFinanceCostsCurrentNet_9b4647ae-6e87-4cf7-a842-1d4d0712b27f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_694760c9-6a6d-4d59-ad19-cf22bf85a6c9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_LongTermDebtCurrentMaturitiesGross_966e8b3e-5f92-4b27-953f-681f5974eba5" xlink:href="shc-20240930.xsd#shc_LongTermDebtCurrentMaturitiesGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_694760c9-6a6d-4d59-ad19-cf22bf85a6c9" xlink:to="loc_shc_LongTermDebtCurrentMaturitiesGross_966e8b3e-5f92-4b27-953f-681f5974eba5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_LongTermDebtGrossNoncurrent_2f8b6bad-108e-4c85-b708-19e7e0ee478b" xlink:href="shc-20240930.xsd#shc_LongTermDebtGrossNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_694760c9-6a6d-4d59-ad19-cf22bf85a6c9" xlink:to="loc_shc_LongTermDebtGrossNoncurrent_2f8b6bad-108e-4c85-b708-19e7e0ee478b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/LongTermDebtScheduleofLongtermDebtInstrumentsDetails_1" xlink:type="simple" xlink:href="shc-20240930.xsd#LongTermDebtScheduleofLongtermDebtInstrumentsDetails_1"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/LongTermDebtScheduleofLongtermDebtInstrumentsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_d75b36fb-2cb6-4768-939d-8b456a95ddb0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_DebtInstrumentUnamortizedDiscountExcludingCurrentPortion_c845c55b-aa4a-476e-a4d6-326e429c0162" xlink:href="shc-20240930.xsd#shc_DebtInstrumentUnamortizedDiscountExcludingCurrentPortion"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_d75b36fb-2cb6-4768-939d-8b456a95ddb0" xlink:to="loc_shc_DebtInstrumentUnamortizedDiscountExcludingCurrentPortion_c845c55b-aa4a-476e-a4d6-326e429c0162" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNoncurrentNet_c62bcbdd-71bf-4d78-9568-386aca94819a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredFinanceCostsNoncurrentNet"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_d75b36fb-2cb6-4768-939d-8b456a95ddb0" xlink:to="loc_us-gaap_DeferredFinanceCostsNoncurrentNet_c62bcbdd-71bf-4d78-9568-386aca94819a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_812e4dea-ae60-4d79-9987-ce63ad18ade3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_d75b36fb-2cb6-4768-939d-8b456a95ddb0" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_812e4dea-ae60-4d79-9987-ce63ad18ade3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/LongTermDebtScheduleofMaturitiesofLongtermDebtDetails" xlink:type="simple" xlink:href="shc-20240930.xsd#LongTermDebtScheduleofMaturitiesofLongtermDebtDetails"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/LongTermDebtScheduleofMaturitiesofLongtermDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_0800798b-bf90-4f7f-ab74-3b98830fa695" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_3d37a552-d32f-4f15-a4fd-5aa4593fd1e0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_0800798b-bf90-4f7f-ab74-3b98830fa695" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_3d37a552-d32f-4f15-a4fd-5aa4593fd1e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_0be1ca19-1e39-4802-9adf-07ff7c23ec9d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_0800798b-bf90-4f7f-ab74-3b98830fa695" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_0be1ca19-1e39-4802-9adf-07ff7c23ec9d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_shc_LongTermDebtMaturityAfterYearFour_f4d303af-491a-416e-bdfd-396f1064f3c2" xlink:href="shc-20240930.xsd#shc_LongTermDebtMaturityAfterYearFour"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_0800798b-bf90-4f7f-ab74-3b98830fa695" xlink:to="loc_shc_LongTermDebtMaturityAfterYearFour_f4d303af-491a-416e-bdfd-396f1064f3c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_ce69e794-ae53-46ec-bc48-20b656fb5fc8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_0800798b-bf90-4f7f-ab74-3b98830fa695" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_ce69e794-ae53-46ec-bc48-20b656fb5fc8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_3788c9eb-ab5c-4f3d-a66b-e537845e9ab2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_0800798b-bf90-4f7f-ab74-3b98830fa695" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_3788c9eb-ab5c-4f3d-a66b-e537845e9ab2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_aaec03b8-4252-4d8d-bd00-3487ce772eae" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_0800798b-bf90-4f7f-ab74-3b98830fa695" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_aaec03b8-4252-4d8d-bd00-3487ce772eae" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/EmployeeBenefitsScheduleofNetPeriodicBenefitCostsDetails" xlink:type="simple" xlink:href="shc-20240930.xsd#EmployeeBenefitsScheduleofNetPeriodicBenefitCostsDetails"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/EmployeeBenefitsScheduleofNetPeriodicBenefitCostsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_ced6dab2-57d9-4641-a64c-9a6b510881d5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanServiceCost_1b34fc52-1b28-4b7e-a30b-a381707f8de6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanServiceCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_ced6dab2-57d9-4641-a64c-9a6b510881d5" xlink:to="loc_us-gaap_DefinedBenefitPlanServiceCost_1b34fc52-1b28-4b7e-a30b-a381707f8de6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_9d1e77b3-649f-45f7-9785-1bd04eaf9d5c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_ced6dab2-57d9-4641-a64c-9a6b510881d5" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_9d1e77b3-649f-45f7-9785-1bd04eaf9d5c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_faba3670-75d9-40c1-85a1-6aad85ecfb55" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanInterestCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_ced6dab2-57d9-4641-a64c-9a6b510881d5" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_faba3670-75d9-40c1-85a1-6aad85ecfb55" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_ba4adf4b-8aa8-41ee-a14b-71eff542cdec" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_ced6dab2-57d9-4641-a64c-9a6b510881d5" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_ba4adf4b-8aa8-41ee-a14b-71eff542cdec" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/OtherComprehensiveIncomeLossDetails" xlink:type="simple" xlink:href="shc-20240930.xsd#OtherComprehensiveIncomeLossDetails"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/OtherComprehensiveIncomeLossDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_d175df60-8720-47d0-a3ac-6762ed962cee" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_6fa3399a-0c6b-4b96-a251-1e82a4e7436d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_d175df60-8720-47d0-a3ac-6762ed962cee" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_6fa3399a-0c6b-4b96-a251-1e82a4e7436d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_abd550be-c816-425d-be9e-7f3be4314140" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_d175df60-8720-47d0-a3ac-6762ed962cee" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_abd550be-c816-425d-be9e-7f3be4314140" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://soterahealth.com/role/EarningsLossPerShareDetails" xlink:type="simple" xlink:href="shc-20240930.xsd#EarningsLossPerShareDetails"/>
  <link:calculationLink xlink:role="http://soterahealth.com/role/EarningsLossPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_ebf463ef-5775-4a3d-b65f-a2b72416668a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesBasic_6a8d3906-e164-4a5d-8225-7ea563f81622" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesBasic"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_ebf463ef-5775-4a3d-b65f-a2b72416668a" xlink:to="loc_us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesBasic_6a8d3906-e164-4a5d-8225-7ea563f81622" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_9737849a-aa82-436c-b8e4-b29cf4737678" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_ebf463ef-5775-4a3d-b65f-a2b72416668a" xlink:to="loc_us-gaap_ProfitLoss_9737849a-aa82-436c-b8e4-b29cf4737678" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_5f6168e1-a245-4d60-b7f3-dafe32ec5db7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_82712c24-8889-46fc-a017-221317adb085" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_5f6168e1-a245-4d60-b7f3-dafe32ec5db7" xlink:to="loc_us-gaap_ProfitLoss_82712c24-8889-46fc-a017-221317adb085" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesDiluted_6634aea9-01bc-402e-b685-42320b9755c9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesDiluted"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_5f6168e1-a245-4d60-b7f3-dafe32ec5db7" xlink:to="loc_us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesDiluted_6634aea9-01bc-402e-b685-42320b9755c9" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
